If you take Depakote for the duration of pregnancy for just about any health-related affliction, your baby is in danger for major birth defects that have an impact on the Mind and spinal cord (for instance spina bifida or neural tube defects). These defects can commence in the main month, even before you know that you are Expecting.

In clients in excess of two many years of age who will be clinically suspected of having a hereditary mitochondrial disorder, Depakote ought to only be made use of immediately after other anticonvulsants have unsuccessful. This more mature team of individuals really should be intently monitored in the course of treatment method with Depakote for the event of acute liver damage with typical scientific assessments and serum liver testing. POLG mutation screening must be executed in accordance with present medical observe [see WARNINGS AND PRECAUTIONS].

Depakote can cause critical Unwanted effects including: See “What exactly is The key data I should learn about Depakote?”

For that reason, no dosage adjustment seems to become essential in clients with renal failure. Protein binding in these clients is substantially lowered; Consequently, checking complete concentrations may very well be misleading.

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There is certainly evidence for severe CNS depression, with or without substantial elevations of barbiturate or valproate serum concentrations. All patients acquiring concomitant barbiturate therapy need to be intently monitored for neurological toxicity. Serum barbiturate concentrations really should be received, if possible, and the barbiturate dosage decreased, if correct. Primidone, and that is metabolized into a barbiturate, may be linked to the same interaction with valproate.

drowsiness or sleepiness within the elderly. This extreme drowsiness might result in you to consume or drink lower than you Typically would. Explain to your healthcare company if You aren't in a position to eat or consume while you Usually do. Your healthcare service provider may possibly start you at a lessen dose of Depakote.

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These highlights tend not to consist of all the knowledge required to use Depakote securely and proficiently. See full prescribing details for Depakote.

Never give Depakote to other people, regardless of whether they have the identical signs or symptoms you have. It may harm them. You may ask your pharmacist or healthcare provider for details about Depakote that is certainly published for health pros.

Depakote is indicated for prophylaxis of migraine headaches. There is no proof that Depakote is useful in the acute procedure of migraine complications.

lower body temperature (hypothermia). A fall in your body temperature to a lot less than 95°F can materialize for check here the duration of treatment with DEPAKOTE. Phone your healthcare company if you have any of the next indications:

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Contact your Health care company instantly For those who have any of these signs and symptoms: severe tummy soreness that you may also experience with your back